Modified-Release Hydrocortisone to Provide Circadian Cortisol Profiles
نویسندگان
چکیده
منابع مشابه
Circadian regulation of cortisol release in behaviorally split golden hamsters.
The master circadian clock located within the hypothalamic suprachiasmatic nucleus (SCN) is necessary for the circadian rhythm of glucocorticoid (GC) release. The pathways by which the SCN sustains rhythmic GC release remain unclear. We studied the circadian regulation of cortisol release in the behaviorally split golden hamster, in which the single bout of circadian locomotor activity splits i...
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BACKGROUND We developed a modified-release hydrocortisone, Chronocort, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption, and it is important to assess their impact when replicating a physiological rhythm. SUBJECTS AND METHODS In vitro dissolution to study impact of alcohol and pH on Chronocort. A phase 1, three-period,...
متن کاملFluorometric measurement of urinary free hydrocortisone (cortisol).
Submitters: Charles R. Ratliff and Frank F. Hall, Section of Biochemistr’.,’, Scott & White Clinic; and Scott & White Hospital Foundation, Temple, Tex. 76501 Evaluators: Thomas W. CuIp, BioRegional Reference Laboratory, Medical Arts Building, San Antonio, Tex. 78205 Christopher S. Frings, Medical Laboratory Associates, 1Q25 South 18th St., Birmingham. Ala. 3520.5 James L. Gilleland and John E. ...
متن کاملAchieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study
OBJECTIVE Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy was developed to provide a cortisol exposure-time profile that closely resembles the physiological cortisol profile. This study aimed to characterize single-dose pharmacokinetics (PK) of DR-HC 5-20mg and assess intrasubject variability. METHODS Thirty-one healthy Japanese or non-Hispanic Caucasian volunteers age...
متن کاملEffect of light intensity on circadian profiles of melatonin, prolactin, ACTH, and cortisol in pigs.
Eleven crossbred barrows were housed in environmentally controlled rooms with an 8-h photoperiod. Pigs in one room received control illumination of 113 1x (CON; n = 6), and pigs in the other room received intense illumination of 1,783 1x (INT; n = 5) fluorescent light. Pigs were given at least 20 d of exposure to the environment before blood samples were taken every 3 h for 48 h. Data were anal...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2009
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2008-2380